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Insumate® - Bitter melon extract

Insumate® - GLP-1 Enhancer / Blood Sugar Control

Insumate® is a bitter melon extract contains the patented peptide sequence mcIRBP™-19, which is a scientifically verified active compound for glucose modulation.
The scientific efficacy of Insumate® has been validated by three official scientific studies. It is easily absorbed by human body due to the low molecular weight of mcIRBP™.-19. The underlying mechanism of glucose modulation has been verified by in-vitro and animal models.

Insumate® (NDIN No. 1256) is also the first USFDA-approved bitter melon product.

Produced using a unique low-temperature, solvent-free supercritical fluid extraction process, Insumate® preserves mcIRBP™-19 integrity and bioactivity, while ensuring high safety and high levels of active compounds. Greenyn is currently the exclusive global provider and ODM partner for Insumate®-based products.

Scientific studies show that Insumate® supports blood sugar and triglycerides balance, and contributes to muscle health, especially in prediabetic individuals.

Product Description

Patented mcIRBP™-19™ Directly Interacts with Insulin Receptors to Support Glucose Control

Insumate®, which contains the patented mcIRBP™-19 peptide, has been demonstrated to directly bind to insulin receptors on the cell membrane, thereby activating downstream insulin signaling pathways. This activation promotes GLUT4 translocation and glucose uptake, contributing to a reduction in fat accumulation and enhanced muscle protein synthesis.
mechanism of Action

Scientific Study

Animal Study	Clinical Study in patients	Clinical Study in Sub-Healthy Individuals
In mice fed a high-fat diet for 8 weeks, Insumate® supplementation resulted in: A significant increase in GLP-1 levels Inhibition of body-weight gain	After taking Insumate® for 12 weeks, it eﬀectively lowered fasting blood glucose and glycated hemoglobin (HbA1c) Around 14% reduction in fasting blood glucose Significant improvement in HbA1c Over 22% reduction in triglycerides	After 12 weeks of Insumate® supplementation, improvements were observed in blood glucose, blood lipid profiles, and muscle mass in individuals with prediabetes. Fasting blood glucose levels remained stable HbA1c decreased to within the normal range Triglyceride levels decreased, and skeletal muscle mass increased

Applications
Insumate® provides multi-path metabolic support with benefits demonstrated in both scientific studies and functional assays:

Glucose Modulation	Fat Management	Whole-Body Health Support
Supports immediate post-meal blood sugar control Prevents rises in fasting blood glucose Helps stabilize insulin levels Contributes to reduced HbA1c	Reduces body fat and prevents muscle atrophy Blocks body-fat formation Helps prevent the increases in blood lipids	Promotes muscle formation and metabolic balance Helps prevent fatty liver Reduces systemic inflammation Serves as an adjuvant support for individuals with diabetes

Characteristics of Insumate^®

Organic solvents-free extraction process, high safety (genotoxicity, acute toxicity, subchronic toxicity, and teratogenic toxicity)
High level of active compound
Multiple international patents and three major international innovation awards
7 published articles including 3 clinical studies
The world’s first USFDA-approved bitter melon product.
Clear underlying mechanism of glucose modulation